Determination of dioxins in a variety of complex sample matrices

In this just released application note, we summarise a comprehensive study completed by van Bavel, et al. that demonstrates the capabilities of Waters' Atmospheric Pressure Gas Chromatography (APGC), coupled with Xevo TQ-S for the determination of dioxins in a variety of complex sample matrices. The performance of APGC was compared to samples previously characterised by GC-HRMS. Finally, system robustness was investigated by an inter-laboratory comparison trial using four different Xevo TQ-S systems with APGC.

Testing has been traditionally performed by GC-EI-HRMS. However, recent technological advances have allowed for a revision of the analytical criteria. Following extensive review, the European Commission has enacted Regulation  EU 589/2014, which permits the use of GC-MS/MS for the confirmatory analysis of dioxins in food and feed.

The authors conclude that the use of APGC in combination with the Xevo TQ-S for the analysis of dioxins has the same potential, in terms of sensitivity and selectivity, as the traditional HRMS instrumentation, and that it is compliant with EU Regulation 589/2014/EU. The APGC-MS/MS benchtop system, however, is far easier to use, maintain, and it can be quickly converted for liquid chromatography analysis.

Download the application note here.