Titrimetric Analysis of Bandages and Wound Care Products

Cationic antiseptics covers a number of compounds differing considerably in chemical type. One of the best and most widely used of the cationic antiseptics is chlorhexidine. Other antiseptics include
products containing (amongstmany others); alcohols, phenols and quaternary ammonium compounds.
Analysis of these active ingredients is important to ensure correct manufacture and dosing levels of these products.
Metrohm have developed a system to analyse some of these actives when they are actually bonded into other wound care products such as bandages or gels.
815 Robotic Titration Soliprep is a system for the fully automated preparation of solid samples that have to be reduced in size and brought into solution.
815 Robotic Titration Soliprep offers fast and comfortable homogenisation and titration of solid samples. Up to 59 samples
with a volume between 50 and 100 mL can be processed in one run.
The sample is weighed into the beaker and placed on the sample rack. The built-in membrane pump adds any aqueous solvents required, while an additional Dosino can be used for adding organic solvents.
This is followed by particle size reduction with the Polytron 1300 D, whose cutting tool is available with or without protruding cutters.
After homogenisation the sample is titrated at the other work station while the Polytron's cutting tool is cleaned at the external rinsing
station. After the titration, electrode and beaker are also automatically emptied and cleaned. Any remaining solid particles
are aspirated simply and rapidly with the 772 Pump Unit. The whole preparation and titration system is controlled by the well-proven tiamoâ„¢titration software, which offers not only flexible control but also an excellent database for managing the titration data produced. Analysis time is quick (typically 3-5 minutes) with excellent
reproducibility.