LC-MS Analysis of PFAS Compounds in EPA Methods 537.1, 533 and 8327

PFAS (Per- and poly-fluoroalkyl substances) are persistent, man-made organic compounds, widely found in the environment. Recent awareness has brought attention to the toxicity of these substances.

The U.S. Food and Drug Administration (FDA) and the U.S. Environmental Protection Agency (EPA) have initiated actions against PFAS. For determination of PFASs, liquid chromatography–mass spectrometry (LC-MS) is a commonly used technique.

EPA has developed, validated, and published three methods to support the analysis of 29 PFAS in drinking water, Method 533, 537 and 537.1. EPA 8327 covers the analysis of selected per- and polyfluoroalkyl substances (PFAS) in prepared extracts of various matrices (e.g., waters and solids) by liquid

chromatography/tandem mass spectrometry (LC/MS/MS) analysis.

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