New In-situ Hydrolysis SPE Plates Announced

Biotage, a leading global supplier of solutions and technology for analytical, medicinal and peptide chemistry, is pleased to announce the launch of EVOLUTE® HYDRO, solid phase extraction plates with an integral Hydrolysis capability that enable chemists to perform sample hydrolysis within the extraction plate; saving time and reducing sample transfer issues.

EVOLUTE® HYDRO Solid Phase Extraction plates gives customers the ability to perform sample (typically urine) hydrolysis within the wells of the extraction plate, followed directly by sample clean up using solid phase extraction, without the need for sample transfer. The Hydro frit technology used by the plates reliably ‘holds up’ both sample and enzyme during incubation at elevated temperatures. This reduces clogging during subsequent clean up steps, leading to robust and streamlined sample preparation. Sample clean-up is performed in the same plate, without the need to transfer samples, saving time and reducing risky sample handling steps.

The plates are packed with high quality 30 µm EVOLUTE® media, with CX (mixed mode strong cation exchange) and ABN (wettable/non-polar) phases available at launch. EVOLUTE® HYDRO can be processed using 96-well compatible positive pressure manifolds (e.g. Biotage® Pressure+ 96), vacuum manifolds (e.g. Biotage® VacMaster™ 96) and automated liquid handling systems (e.g. Biotage® Extrahera™).

“By combining our unique Hydro frit technology with our wettable EVOLUTE® sorbents, the new SPE plates allow the hydrolysed sample to be loaded directly onto the SPE bed for clean-up. The conditioning and equilibration steps are eliminated, saving time and reducing costs.” said Dr Claire Desbrow, Global Product Manager, Analytical Chemistry, Biotage.